Saudi Electricity has patented a method for live-cell imaging using catenane compositions. The method involves contacting a cell with a catenane, irradiating the cell, and detecting exciplex emission from the catenane within the cell. The catenane comprises two mechanically interlocked macrocycles with aromatic fluorophores arranged for emission. GlobalData’s report on Saudi Electricity gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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Live-cell imaging method using catenane with exciplex emission
A recently granted patent (Publication Number: US11977028B2) discloses a method for live-cell imaging using a catenane compound. The method involves contacting a cell with a catenane containing two mechanically interlocked macrocycles, each comprising an aromatic fluorophore subunit arranged in a face-to-face [p . . . p] stack. Upon irradiation of the cell, exciplex emission from the catenane is detected, allowing for live-cell imaging.
Specific embodiments of the method include the catenane containing an anthracene subunit, an anthracene-bypyridine subunit, or a 2,6-anthracene-bypyridine subunit. The effective amount of the catenane used is less than 10×10-6 M, and the detected emission has a wavelength greater than 600 nm. Additionally, the cell is irradiated with a wavelength less than 500 nm, and the catenane is octacationic. The method can be performed in vitro, and a specific catenane mentioned is 2,6AnHC8+. These claims outline the specific parameters and components of the method for live-cell imaging using the described catenane compound.
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